NLS - DIAGNoStIcS oF LuNG cANcer

mAterIAL AND metHoDS Objective of this study is to evaluate diagnostic potentials of NLSresearch and identifying of NLS-graphic semiotics of lung cancer various forms. NLS-research was carried out by hardware-software system «Metatron»-4025 with «Metapathia GR Clinical» software that allows us to carry out 3D visualization of organs and histological substrates, carry out spectral-entropy analysis (SEA) of affection nidus tissues and lymph nodes in order to identify non-invasively their pathomorphological character. All researches were verified by results of operative interventions and date of histological examination of surgical and biopsy material. To evaluate potentials of NLS-graphy in pathological neoplasm detection and verification of affection nidus, we carried out roentgenography of chest in two projections prior to NLS-research in majority of cases. With three-dimensional NLS-graphy we evaluated size, chromogeneity, structure of nidus, outlines and its interaction with surrounding tissues. In all cases we examined pleural cavity to detect pleural effusion and evaluate its volume. We carried out supraand parasternal examination of upper mediastinum to exclude metastatic affection of intraaorticpulmonary and paratracheal lymph nodes. If it was necessary we examined lymph nodes of supraclavicular and front-neck area. NLS-graphy with SEA detected symptoms of malignant process in lungs in 146 patients, in 63 of them peripheral cancer of lung was diagnosed, in 61 – obturator atelectasis of lung lobe or segment (in 11 of them we located tumor itself in root of lung), in 9 patients we detected tumors of non-epithelial nature. Exudative pleurisy of tumorous etiology was diagnosed in 30 patients, in 17 of them it was monitored together with other spectral signs of malignant process, in 13 patients it was the only presentation of lung cancer detected by evaluation of spectral similarity with etalon blast processes.